Douglas R Spitz Selected Research

Methionine Sulfoxide Reductases

1/2018	Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription.
11/2011	Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.
5/2008	A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation.

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Douglas R Spitz Research Topics

Disease

85	Neoplasms (Cancer) 01/2022 - 11/2002
18	Breast Neoplasms (Breast Cancer) 01/2017 - 08/2003
9	Head and Neck Neoplasms (Head and Neck Cancer) 12/2021 - 04/2007
9	Carcinogenesis 01/2019 - 07/2006
8	Genomic Instability 09/2021 - 08/2006
8	Pancreatic Neoplasms (Pancreatic Cancer) 01/2020 - 07/2004
7	Carcinoma (Carcinomatosis) 11/2015 - 07/2002
6	Mitochondrial Diseases (Mitochondrial Disease) 07/2019 - 01/2009
5	Inflammation (Inflammations) 01/2022 - 05/2003
5	Adenocarcinoma 12/2021 - 04/2010
5	Squamous Cell Carcinoma of Head and Neck 12/2021 - 01/2009
5	Lung Neoplasms (Lung Cancer) 01/2020 - 10/2011
5	Prostatic Neoplasms (Prostate Cancer) 01/2015 - 07/2005
5	Infections 01/2014 - 08/2005
4	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2022 - 01/2017
4	Glioblastoma (Glioblastoma Multiforme) 01/2021 - 10/2008
4	Colonic Neoplasms (Colon Cancer) 01/2020 - 07/2009
3	Neuroblastoma 04/2016 - 04/2008
3	Necrosis 10/2013 - 11/2005
3	Myocardial Infarction 11/2011 - 11/2005
2	Colitis 01/2022 - 05/2003
2	Acute Kidney Injury (Acute Renal Failure) 08/2021 - 01/2019
2	Chronic Renal Insufficiency 08/2021 - 01/2019
2	Wounds and Injuries (Trauma) 08/2021 - 08/2020
2	Uterine Cervical Neoplasms (Cancer of the Cervix) 12/2020 - 01/2018
2	Sarcoma (Soft Tissue Sarcoma) 08/2020 - 01/2018
2	Melanoma (Melanoma, Malignant) 01/2020 - 01/2020
2	Colorectal Neoplasms (Colorectal Cancer) 01/2020 - 08/2015
2	Hypoxia (Hypoxemia) 01/2020 - 12/2005
2	Neoplasm Metastasis (Metastasis) 01/2020 - 12/2012
2	Multiple Myeloma 01/2016 - 12/2010
2	Ovarian Neoplasms (Ovarian Cancer) 11/2015 - 03/2009
2	Reperfusion Injury 07/2015 - 11/2005
2	Fibrosis (Cirrhosis) 03/2014 - 08/2003
2	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2012 - 04/2011

Drug/Important Bio-Agent (IBA)

25	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2020 - 05/2005
22	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 12/2021 - 07/2005
19	Superoxides (Superoxide)IBA 12/2021 - 07/2006
18	Sulfhydryl Compounds (Thiols)IBA 12/2020 - 06/2003
18	Glucose (Dextrose)FDA LinkGeneric 01/2017 - 11/2002
16	Glutathione (Reduced Glutathione)IBA 12/2021 - 02/2006
15	Superoxide DismutaseIBA 12/2021 - 04/2003
14	Proteins (Proteins, Gene)FDA Link 01/2021 - 07/2002
14	AntioxidantsIBA 11/2015 - 08/2003
13	EnzymesIBA 09/2021 - 05/2003
12	Deoxyglucose (2 Deoxy D glucose)IBA 01/2016 - 02/2006
10	Pharmaceutical PreparationsIBA 01/2020 - 05/2003
9	ThioredoxinsIBA 12/2021 - 01/2009
9	IronIBA 09/2021 - 08/2003
8	CatalaseIBA 12/2021 - 03/2007
7	Auranofin (Ridaura)FDA Link 12/2021 - 10/2011
7	Cisplatin (Platino)FDA LinkGeneric 08/2021 - 04/2007
6	Acetylcysteine (Siran)FDA LinkGeneric 01/2020 - 05/2005
6	Glutathione Disulfide (GSSG)FDA LinkGeneric 01/2020 - 02/2008
6	Ascorbic Acid (Vitamin C)FDA LinkGeneric 01/2020 - 01/2018
5	Buthionine SulfoximineIBA 12/2021 - 10/2011
5	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2018
5	Carboplatin (JM8)FDA LinkGeneric 01/2020 - 10/2011
5	Small Interfering RNA (siRNA)IBA 06/2011 - 03/2007
4	Thioredoxin-Disulfide ReductaseIBA 01/2020 - 05/2006
4	CopperIBA 01/2020 - 07/2006
4	MetalsIBA 01/2018 - 01/2017
3	PlatinumIBA 01/2022 - 11/2016
3	avasopasem manganeseIBA 12/2021 - 01/2017
3	DNA (Deoxyribonucleic Acid)IBA 09/2021 - 01/2012
3	Saccharated Ferric Oxide (Venofer)FDA Link 01/2020 - 01/2017
3	Gemcitabine FDA Link 12/2018 - 06/2011
3	NAD (NADH)IBA 01/2018 - 11/2006
3	Methionine Sulfoxide ReductasesIBA 01/2018 - 05/2008
3	Oxidoreductases (Dehydrogenase)IBA 10/2016 - 11/2006
3	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 01/2014 - 04/2010
3	Cysteine (L-Cysteine)FDA Link 01/2012 - 02/2008
3	Drug CombinationsIBA 01/2012 - 02/2006
3	Free RadicalsIBA 01/2012 - 07/2006
3	Sirtuin 3IBA 01/2011 - 01/2010
3	Antimycin AIBA 07/2009 - 12/2006
2	CarbohydratesIBA 01/2021 - 01/2014
2	Temozolomide (Temodar)FDA LinkGeneric 01/2021 - 11/2019
2	Glutamine (L-Glutamine)FDA Link 12/2020 - 01/2019
2	Chelating AgentsIBA 01/2020 - 01/2017
2	CollagenIBA 12/2018 - 04/2011
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2018 - 04/2010
2	NADP (NADPH)IBA 01/2018 - 02/2008
2	matrigelIBA 10/2016 - 12/2012
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 04/2016 - 04/2008
2	RetinoidsIBA 04/2016 - 04/2008
2	Adrenergic Agents (Adrenergic Drugs)IBA 11/2015 - 11/2011
2	PentosesIBA 01/2015 - 09/2009
2	AldehydesIBA 01/2014 - 11/2005
2	Aldehyde DehydrogenaseIBA 01/2014 - 12/2012
2	FatsIBA 01/2014 - 07/2013
2	beta-lapachoneIBA 10/2013 - 11/2006
2	quinone (benzoquinone)IBA 10/2013 - 11/2006

Therapy/Procedure

37	Therapeutics 10/2021 - 07/2004
19	Drug Therapy (Chemotherapy) 01/2022 - 03/2008
9	Radiotherapy 12/2021 - 06/2008
4	Ketogenic Diet 01/2021 - 07/2013
2	Immunotherapy 01/2022 - 01/2020
2	Intravenous Infusions 01/2019 - 12/2018
2	Intravenous Administration 01/2019 - 01/2018